Widespread distribution of immunoreactive thyroid hormone beta 2 receptor (TR beta 2) in the nuclei of extrapituitary rat tissues.
نویسندگان
چکیده
منابع مشابه
THRB (Thyroid Hormone Receptor, Beta)
Review on THRB, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
متن کاملIsoform-specific 3,5,3'-triiodothyronine receptor binding capacity and messenger ribonucleic acid content in rat adenohypophysis: effect of thyroidal state and comparison with extrapituitary tissues.
Although the role of the three functional thyroid hormone receptor isoforms (TR beta 1, TR beta 2, and TR alpha 1) remains unclear, studies by Hodin and Lazar et al. have suggested that restriction of TR beta 2 messenger RNA (mRNA) to rat pituitary could reflect a specific regulatory role in the pituitary. Supporting their hypothesis was a significant fall in pituitary TR beta 2 mRNA after T3 a...
متن کاملSpared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.
Thyrotoxicosis is frequently associated with increased bone turnover and decreased bone mass. To investigate the role of thyroid hormone receptor-beta (TR beta) in mediating the osteopenic effects of triiodothyronine (T3), female adult rats were treated daily (64 days) with GC-1 (1.5 microg/100 g body wt), a TR beta-selective thyromimetic compound. Bone mass was studied by dual-energy X-ray abs...
متن کاملEpigenetic Regulation of Thyroid Hormone Receptor Beta in Renal Cancer
Thyroid hormone receptor beta (THRB) gene is commonly deregulated in cancers and, as strengthened by animal models, postulated to play a tumor-suppressive role. Our previous studies revealed downregulation of THRB in clear cell renal cell carcinoma (ccRCC), but the culpable mechanisms have not been fully elucidated. Since epigenetic regulation is a common mechanism influencing the expression of...
متن کاملBeta-2 adrenergic receptor
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream Ltype calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Unlike other adr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)31459-x